Malignant Tumors of the Liver Other Than HCC
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VOLUME: 14 ISSUE: 1
P: 114 - 129
April 2026

Malignant Tumors of the Liver Other Than HCC

Turk Radiol Semin 2026;14(1):114-129
1. İstanbul Üniversitesi İstanbul Tıp Fakültesi, Radyoloji Anabilim Dalı, İstanbul, Türkiye
No information available.
No information available
Received Date: 06.03.2026
Accepted Date: 20.04.2026
Online Date: 27.04.2026
Publish Date: 27.04.2026
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ABSTRACT

Rare and atypical liver malignancies constitute a complex spectrum that complicates differential diagnosis by radiologically mimicking hepatocellular carcinoma. Identifying specific contrast kinetics in metastases, cholangiocarcinoma, mesenchymal, and neuroendocrine tumors can protect patients from inappropriate surgical interventions and chemotherapy.

Keywords:
Liver neoplasms, differential diagnosis, magnetic resonance imaging, atypical hepatic lesions

References

1
Mamone G, Di Piazza A, Carollo V, Crinò F, Vella S, Cortis K, et al. Imaging of primary malignant tumors in non-cirrhotic liver. Diagn Interv Imaging. 2020; 101: 519-35.
2
Ludwig DR, Fraum TJ, Cannella R, Ballard DH, Tsai R, Naeem M, et al. Hepatocellular carcinoma (HCC) versus non-HCC: accuracy and reliability of Liver Imaging Reporting and Data System v2018. Abdom Radiol (NY). 2019; 44: 2116-32.
3
Gore RM, Thakrar KH, Wenzke DR, Newmark GM, Mehta UK, Berlin JW. That liver lesion on MDCT in the oncology patient: is it important? Cancer Imaging. 2012; 12: 373-84.
4
Ozaki K, Higuchi S, Kimura H, Gabata T. Liver metastases: correlation between imaging features and pathomolecular environments. Radiographics. 2022; 42: 1994-2013.
5
Frenette C, Mendiratta-Lala M, Salgia R, Wong RJ, Sauer BG, Pillai A. ACG clinical guideline: focal liver lesions. Am J Gastroenterol. 2024; 119: 1235-71.
6
Park YS, Lee CH, Kim JW, Shin S, Park CM. Differentiation of hepatocellular carcinoma from its various mimickers in liver magnetic resonance imaging: what are the tips when using hepatocyte-specific agents? World J Gastroenterol. 2016; 22: 284-99.
7
Jensen CT, Gupta S, Saleh MM, Liu X, Wong VK, Salem U, et al. Reduced-dose deep learning reconstruction for abdominal CT of liver metastases. Radiology. 2022; 303: 90-8.
8
Küçük NÖ, İnal G, Soydal Ç. PET/MR imaging in liver tumors. Nucl Med Semin. 2024; 10: 313-21.
9
Joo I, Lee JM, Yoon JH. Imaging diagnosis of intrahepatic and perihilar cholangiocarcinoma: recent advances and challenges. Radiology. 2018; 288: 7-13.
10
European Association for the Study of the Liver. EASL-ILCA Clinical Practice Guidelines on the management of intrahepatic cholangiocarcinoma. J Hepatol. 2023; 79: 181-208. Epub 2023 Apr 20. Erratum in: J Hepatol. 2023; 79: 1342.
11
Gorji L, Beal EW. Surgical treatment of distal cholangiocarcinoma. Curr Oncol. 2022; 29: 6674-87.
12
Lee MH, Katabathina VS, Lubner MG, Shah HU, Prasad SR, Matkowskyj KA, et al. Mucin-producing cystic hepatobiliary neoplasms: updated nomenclature and clinical, pathologic, and imaging features. Radiographics. 2021; 41: 1592-610.
13
Stanietzky N, Salem AE, Elsayes KM, Rezvani M, Palmquist S, Ahmed I, et al. Unusual liver tumors: spectrum of imaging findings with pathologic correlation. Diagn Interv Radiol. 2025; 31: 58-67.
14
Anand S, Chandrasekar S, Raja K, Pottakkat B. Mucinous cystic neoplasm of the liver with biliary communication: an exception to the current classification. BMJ Case Rep. 2019; 12: bcr-2018-227063.